70-51-9 MSDS - Deferoxamine
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Deferoxamine

Identification
Name Deferoxamine
CAS Registry Number 70-51-9
Synonyms 1-amino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(n-acetylhydroxylamino)-6,11,17,;22-tetraazaheptaeicosane;3,9,14,20,25-pentaazatriacontane-2,10,13,21,24-pentone,30-amino-3,14,25-trih;3,9,14,20,25-pentaazatriacontane-2,10,13,21,24-pentone,30-amino-3,14,25-trihyd;30-amino-3,14,25-trihydroxy-3,9,14,20,25-pentaazatriacontane-2,10,13,21,24-p;30-amino-3,14,25-trihydroxy-3,9,14,20,25-pentaazatriacontane-2,10,13,21,24-pen;acetamido)pentyl]carbamoyl]propionohydroxamicacid;ba-29837
Molecular Structure Deferoxamine   70-51-9
Molecular Formula C25H48N6O8
Molecular Weight 560.68
Supplier
Lightchem Inc
Supply Precious metal catalyst
OLED Materials etc.
www.lightchem.com
 
Wiki & MSDS
70-51-9.pdf
Deferoxamine
Deferoxamine-2D-skeletal.png
Deferoxamine-3D-vdW.png
Skeletal formula and spacefill model of deferoxamine
Clinical data
Trade names Desferal
AHFS/Drugs.com Monograph
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
  • intramuscular
  • intravenous
  • subcutaneous
ATC code
  • V03AC01 (WHO)
Pharmacokinetic data
Biological half-life 6 hours
Identifiers
Synonyms desferrioxamine B, desferoxamine B, DFO-B, DFB ,N'-[5-(Acetyl-hydroxy-amino)pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl) propanoylamino]pentyl]-N-hydroxy-butane diamide
CAS Number
  • 70-51-9
PubChem CID
  • 2973
DrugBank
  • DB00746
ChemSpider
  • 2867
UNII
  • J06Y7MXW4D
KEGG
  • D03670
ChEBI
  • CHEBI:4356
ChEMBL
  • CHEMBL556
ECHA InfoCard 100.000.671
Chemical and physical data
Formula C25H48N6O8
Molar mass 560.69 g·mol−1
3D model (Jmol)
  • Interactive image

Deferoxamine (DFOA), sold under the brand name Desferal, is a medication that binds iron and aluminium.[1] It is specifically used in iron overdose, hemochromatosis either due to multiple blood transfusions or an underlying genetic condition, and aluminium toxicity in people on dialysis.[1][2] It is used by injection into a muscle, vein, or under the skin.[1]

Common side effects include pain at the site of injection, diarrhea, vomiting, fever, hearing loss, and eye problems. Severe allergic reactions including anaphylaxis and low blood pressure may occur.[1] It is unclear if use during pregnancy or breastfeeding is safe for the baby.[3] Deferoxamine is a siderophore from the bacteria Streptomyces pilosus.[4]

Deferoxamine was approved for medical use in the United States in 1968.[1] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] The wholesale cost in the developing world is about 6.76 to 13.52 USD per dose.[6] In the United States a course of treatment costs more than 200 USD.[7]


 







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